Drosophila melanogasterGenAge entry for Gpdh (Drosophila melanogaster)

Gene information (ID: 2152)

Symbol
Gpdh
Name
Glycerol 3 phosphate dehydrogenase
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
A mutation that decreased Gpdh activity (59.6% of the wildtype) in flies increased lifespan by 20%. This difference in lifespan was also observed between mutant and wild type flies subjected to dietary restriction.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Caenorhabditis elegans
    gpdh-2
    Danio rerio
    gpd1l
    Homo sapiens
    GPD1L
    Mus musculus
    Gpd1l
    Rattus norvegicus
    Gpd1l

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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