Mus musculusGenAge entry for Gdf15 (Mus musculus)

Gene information (ID: 1871)

Symbol
Gdf15
Name
growth differentiation factor 15
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Female hNAG-1 mice (mice expressing hNAG-1/hGDF15) have significantly increased mean and median life spans in two transgenic lines. The effect is stronger in mice on high fat diet than on low fat diet. hNAG-1 mice display reduced body and adipose tissue weight, lowered serum IGF-1, insulin and glucose levels, improved insulin sensitivity, and increased oxygen utilization, oxidative metabolism and energy expenditure.
% change in avg or median lifespan
Female mean lifespan is up to 43% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Homo sapiens
    GDF15
    Rattus norvegicus
    Gdf15

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (23886)
    Homologues
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    UniProt
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    Internet
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