Drosophila melanogasterGenAge entry for Gadd45 (Drosophila melanogaster)

Gene information (ID: 849)

Symbol
Gadd45
Aliases
BcDNA:RH70774; CG11086; D-GADD45; Dmel\CG11086; GADD45
Name
CG11086 gene product from transcript CG11086-RA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of the D-GADD45 gene in the nervous system leads to a significantly increase of Drosophila lifespan without a decrease in fecundity and locomotor activity. The lifespan extension effect is more pronounced in males than in females. In addition an increase in maximum life span was detected.
% change in max lifespan
Maximum male lifespan is up to 59% higher; Maximum female lifespan is up to 50% higher.
% change in avg or median lifespan
Median male lifespan is up to 77% higher; Median female lifespan is up to 46% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    gadd45bb
    Homo sapiens
    GADD45B
    Mus musculus
    Gadd45b
    Rattus norvegicus
    Gadd45a

    External links

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    Entrez Gene
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    Internet
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