Drosophila melanogasterGenAge entry for GLaz (Drosophila melanogaster)

Gene information (ID: 305)

Symbol
GLaz
Aliases
CG4604; DGLaz; Dmel\CG4604
Name
Glial Lazarillo
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Carrier of hydrophobic substances

Potential relevance to longevity and/or ageing

Observations
Overexpression resulted in increased resistance to hyperoxia and a 29% extension of mean lifespan under normoxia. Lifespan was also extended 30-60% under starvation.
% change in avg or median lifespan
Average lifespan is 29% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    The absence of GLaz reduces the organism's resistance to oxidative stress and starvation and shortens male lifespan. Median survival time is reduced by 19.3%, maximum survival time is reduced by 10.9%.
    % change in max lifespan
    Maximum lifespan is 10.9% lower.
    % change in avg or median lifespan
    Median lifespan is 19.3% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

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      Entrez Gene
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