Mus musculusGenAge entry for Fxn (Mus musculus)

Gene information (ID: 290)

Symbol
Fxn
Aliases
FA; X25; FARR; Frda
Name
frataxin
Organism
Mus musculus (AnAge)
Known functions and activities
Regulation of mitochondrial iron transport and respiration

Potential relevance to longevity and/or ageing

Observations
Disruption results in reduced lifespan, increased oxidative stress, impaired respiration, and the development of hepatic tumors.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as frh-1
    • A homolog of this gene for Drosophila melanogaster is present as fh

    Homologs in other organisms

    Caenorhabditis elegans
    frh-1
    Danio rerio
    fxn
    Drosophila melanogaster
    fh
    Homo sapiens
    FXN
    Rattus norvegicus
    Fxn
    Schizosaccharomyces pombe
    SPCC1183.03c

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (14297)
    Homologues
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    UniProt
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    Internet
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