Saccharomyces cerevisiaeGenAge entry for FOB1 (Saccharomyces cerevisiae)

Gene information (ID: 284)

Symbol
FOB1
Aliases
HRM1
Name
Fob1p
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Knocking out this gene extends lifespan by 30-50%.
% change in avg or median lifespan
Lifespan is 30-50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Deletion of fob1 causes extension in the short life span of the sir2 mutant extended by ~50%
    % change in avg or median lifespan
    Replicative lifespan is approximately 50% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      About 20% mean replicative lifespan increase
      % change in avg or median lifespan
      Replicative lifespan is 20% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Deletion
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Replicative lifespan increased by 25% in the alpha strain and by 10% in a strain
        % change in avg or median lifespan
        Replicative lifespan is 10-25% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Deletion
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          Mean chronological lifespan strongly increased in the a strain
          Lifespan Effect
          Increase
          Genetic Manipulation
          Deletion
          Longevity Category
          Anti-Longevity
          Primary reference

            Homologs in other organisms

            Homo sapiens
            KRBA2

            External links

            Saccharomyces Genome Database
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            Ensembl
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            Entrez Gene
            View on Entrez Gene database (851688)
            Homologues
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            UniProt
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            Internet
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