Drosophila melanogasterGenAge entry for Dys (Drosophila melanogaster)

Gene information (ID: 843)

Symbol
Dys
Aliases
CG17750; CG31175; CG34157; CG7240; CG7243; CG7344; det; D
Name
Dystrophin
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
The loss of dys function in the heart leads to an age-dependent disruption of the myofibrillar organization within the myocardium as well as to alterations in cardiac performance. dys RNAi-mediated knockdown in the mesoderm also shortens lifespan. A moderate maximal lifespan reduction in the mesodermal dys knockdown flies (13%) was observed, but not when exclusively targeted to the heart. In contrast, half of the transheterozygous DysExel6184/Dyskx43 deficiency flies died at 29 days compared to 63 days in controls.This suggests that a moderate dys loss-of-function in all muscles, but not in just the heart, reduces the fly
% change in max lifespan
Maximum lifespan is 13% lower.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference and deletion
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Dmd

    Homologs in other organisms

    Caenorhabditis elegans
    dys-1
    Danio rerio
    dmd
    Homo sapiens
    UTRN
    Mus musculus
    Dmd
    Rattus norvegicus
    uncharacterized_F1M7

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42327)
    Homologues
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    UniProt
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    Internet
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