Saccharomyces cerevisiaeGenAge entry for DIE2 (Saccharomyces cerevisiae)

Gene information (ID: 1532)

Symbol
DIE2
Aliases
ALG10
Name
Derepression of ITR1 Expression
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion of die2, a target of the unfolded protein response signaling, decreases replicative lifespan.
% change in avg or median lifespan
Mean lifespan is 17% lower.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mean chronological lifespan increased in the a strain by less than 50% but more than 15%
    % change in avg or median lifespan
    Mean chronological lifespan is 15%-50% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference

      Homologs in other organisms

      Caenorhabditis elegans
      tag-179
      Danio rerio
      alg10
      Drosophila melanogaster
      Alg10
      Homo sapiens
      ALG10
      Mus musculus
      Alg10b
      Rattus norvegicus
      Alg10b
      Schizosaccharomyces pombe
      alg10

      External links

      Saccharomyces Genome Database
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (853142)
      Homologues
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      UniProt
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      Internet
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