Mus musculusGenAge entry for Chek2 (Mus musculus)

Gene information (ID: 122)

Symbol
Chek2
Aliases
CHK2; Cds1; Rad53; HUCDS1
Name
CHK2 checkpoint homolog (S. pombe)
Organism
Mus musculus (AnAge)
Known functions and activities
Cell cycle checkpoint regulator

Potential relevance to longevity and/or ageing

Observations
Mice hypomorphic for Brca1 and double mutant for chk2 exhibit signs of premature ageing.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as DUN1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as CHEK2

    Homologs in other organisms

    Caenorhabditis elegans
    chk-2
    Danio rerio
    chek2
    Drosophila melanogaster
    lok
    Homo sapiens
    CHEK2
    Rattus norvegicus
    Chek2
    Saccharomyces cerevisiae
    DUN1
    Schizosaccharomyces pombe
    cds1

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (50883)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar