Drosophila melanogasterGenAge entry for Cbs (Drosophila melanogaster)

Gene information (ID: 1791)

Symbol
Cbs
Aliases
CBS; CG1753; dCBS; Dmel\CG1753
Name
Cystathionine beta-synthase
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Adult-specific ubiquitous overexpression of dCBS increases female mean and maximum lifespan by 12 - 43% and 10%, respectively. Males exhibit a smaller, but still significant increase in lifespan by 7% upon dCBS overexpression. Neuronal overexpression also increases lifespan, albeit modestly (approximately 12% mean and 15% maximum lifespan extension), whereas overexpression in the fat body and in the gut has no effect.
% change in avg or median lifespan
Average lifespan is up to 43% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as CYS4
    GenDR gene manipulations
    • This gene is present as Cbs

    Homologs in other organisms

    Caenorhabditis elegans
    cysl-4
    Danio rerio
    cbsa
    Homo sapiens
    CBS
    Mus musculus
    Cbs
    Rattus norvegicus
    Cbs
    Saccharomyces cerevisiae
    CYS4
    Schizosaccharomyces pombe
    cys12

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (33081)
    Homologues
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    UniProt
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    Internet
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