Mus musculusGenAge entry for Casp2 (Mus musculus)

Gene information (ID: 90)

Symbol
Casp2
Aliases
ICH-1; Nedd2; Caspase-2
Name
caspase 2
Organism
Mus musculus (AnAge)
Known functions and activities
Apoptosis

Potential relevance to longevity and/or ageing

Observations
Loss of caspase-2 resulted in a shortened (10%) maximum lifespan and in enhanced ageing-related traits such as impaired hair growth, increased bone loss, and reduced body fat content.
% change in max lifespan
Maximum lifespan is 10% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as ced-3

    Homologs in other organisms

    Caenorhabditis elegans
    ced-3
    Danio rerio
    casp2
    Homo sapiens
    CASP2
    Rattus norvegicus
    Casp2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (12366)
    Homologues
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    UniProt
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    Internet
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