Saccharomyces cerevisiaeGenAge entry for CYR1 (Saccharomyces cerevisiae)

Gene information (ID: 149)

Symbol
CYR1
Aliases
CDC35; FIL1; HSR1; SRA4; TSM0185
Name
Adenylate cyclase
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
The CDC35-1 allele confers a 75% extension of replicative life span at 25 C
% change in avg or median lifespan
Replicative lifespan is 75% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, increase resistance to oxidants and extend LS by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension. A transposon mutagenized allele of CYR1 extends chronological life span, as measured by stationary phase survival, by 90%.
    % change in avg or median lifespan
    Chronological lifespan is 90% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutations
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Knocking out gene extends replicative lifespan by 75%.
      % change in avg or median lifespan
      Replicative lifespan is 75% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Knockout
      Longevity Category
      Anti-Longevity
      Primary reference

        In other databases

        GenDR gene manipulations
        • This gene is present as CYR1

        Homologs in other organisms

        Schizosaccharomyces pombe
        cyr1

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (853452)
        Homologues
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        UniProt
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        Internet
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