Saccharomyces cerevisiaeGenAge entry for CHL1 (Saccharomyces cerevisiae)

Gene information (ID: 126)

Symbol
CHL1
Aliases
CTF1; LPA9; MCM12
Name
Chl1p
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Required to establish sister-chromatid pairing

Potential relevance to longevity and/or ageing

Observations
It may modulate transcriptional silencing in the presence of Sir proteins. Knockouts exhibit a shortened lifespan and are hypersensitivity to heat stress.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Necessary for fitness
Primary reference
    Observations
    Mean chronological lifespan decreased in the a strain by less than 50% but more than 15%
    % change in avg or median lifespan
    Mean chronological lifespan is 15%-50% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Necessary for fitness
    Primary reference

      Homologs in other organisms

      Caenorhabditis elegans
      chl-1
      Danio rerio
      ddx11
      Drosophila melanogaster
      EG:33C11.2
      Homo sapiens
      DDX11
      Mus musculus
      Ddx11
      Rattus norvegicus
      Ddx11
      Schizosaccharomyces pombe
      chl1

      External links

      Saccharomyces Genome Database
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (856099)
      Homologues
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      UniProt
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      Internet
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