Drosophila melanogasterGenAge entry for CG42358 (Drosophila melanogaster)

Gene information (ID: 1854)

Symbol
CG42358
Aliases
CG5558; Dmel\CG42358
Name
CG42358
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference of dNsun5 extends mean lifespan of worms by 16-20%. High nutrient diet abrogated this effect.
% change in avg or median lifespan
Mean lifespan is up to 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Overexpression of dNsun5 reduces mean lifespan by 58%.
    % change in avg or median lifespan
    Mean lifespan is 58% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Overexpression
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Caenorhabditis elegans is present as nsun-5

      Homologs in other organisms

      Caenorhabditis elegans
      CELE_Y53F4B.4
      Danio rerio
      nsun5
      Homo sapiens
      NSUN5P2
      Mus musculus
      Nsun5
      Rattus norvegicus
      Nsun5
      Schizosaccharomyces pombe
      SPAC2C4.06c

      External links

      FlyBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (7354421)
      Homologues
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      UniProt
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      Internet
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