Caenorhabditis elegansGenAge entry for CELE_W09C5.8 (Caenorhabditis elegans)

Gene information (ID: 729)

Symbol
CELE_W09C5.8
Name
Protein W09C5.8
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Cytochrome c oxidase, subunit IV/COX5b

Potential relevance to longevity and/or ageing

Observations
RNA interference extends lifespan about 60%.
% change in avg or median lifespan
Lifespan is about 60% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi resulted in lifespan extension.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      60-100% extended mean lifespan when inactivated post developmentally, in different backgrounds.
      % change in avg or median lifespan
      Average lifespan is 60-100% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        RNAi led to a 40% mean lifespan extension.
        % change in avg or median lifespan
        Average lifespan is 40% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference

          Homologs in other organisms

          Danio rerio
          LOC402880
          Drosophila melanogaster
          CoIV
          Homo sapiens
          COX4I2
          Mus musculus
          Cox4i2
          Rattus norvegicus
          Cox4i2

          External links

          WormBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (173237)
          Homologues
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          UniProt
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          Internet
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