Mus musculusGenAge entry for Brca1 (Mus musculus)

Gene information (ID: 48)

Symbol
Brca1
Name
Breast cancer 1
Organism
Mus musculus (AnAge)
Known functions and activities
Maintenance of genomic stability

Potential relevance to longevity and/or ageing

Observations
Deletion causes senescence in mutant embryos and cultured cells and tumorigenesis and signs of premature ageing in adult mice.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Brca1 heterozygotes appear to have a shortened life span with 70% tumor incidence. Lymphoma, but not ovarian and mammary gland tumors, occurs commonly in these mice. After a whole-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3-5-fold higher incidence specific to ovarian tumors, but not lymphoma, when compared with the Brca1+/+ mice.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Pro-Longevity
    Primary reference

      In other databases

      GenAge human genes
      • A homolog of this gene for Homo sapiens is present as BRCA1
      LongevityMap
      • A homolog of this gene for Homo sapiens is present as BRCA1
      CellAge
      • A homolog of this gene for Homo sapiens is present as BRCA1

      Homologs in other organisms

      Homo sapiens
      BRCA1
      Rattus norvegicus
      Brca1

      External links

      Mouse Genome Informatics
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (12189)
      Homologues
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      UniProt
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      Internet
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