Mus musculusGenAge entry for Atr (Mus musculus)

Gene information (ID: 30)

Symbol
Atr
Name
Ataxia telangiectasia and Rad3 related
Organism
Mus musculus (AnAge)
Known functions and activities
DNA repair and cell cycle control

Potential relevance to longevity and/or ageing

Observations
Deletion in young adults eliminates 80-90% of proliferating cells and results in several age-related phenotypes accompanied by a depletion of stem and progenitor cells and exhaustion of tissue renewal and homeostatic capacity.
Lifespan Effect
Decrease
Genetic Manipulation
Deletion
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mutant mice show high levels of replicative stress during embryogenesis, when proliferation is widespread, but this is reduced to marginal amounts in postnatal life. In spite of this decrease, adult Seckel mice show accelerated aging, which is further aggravated in the absence of p53. Seckel mice died in less than half a year, showing pancytopenia, cachexia and signs of premature ageing, including hair graying, kyphosis, osteoporosis, accumulation of fat in the bone marrow, decreased density of hair follicles and thinner epidermis.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutations
    Longevity Category
    Pro-Longevity
    Primary reference

      Homologs in other organisms

      No homologs found

      External links

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      Internet
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