Drosophila melanogasterGenAge entry for Atg8a (Drosophila melanogaster)

Gene information (ID: 22)

Symbol
Atg8a
Aliases
atg8; Atg8; Atg8/LC3; atg8a; Atg8A; ATG8a; BcDNA:LD05816
Name
Autophagy-related 8a
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Involved in autophagy

Potential relevance to longevity and/or ageing

Observations
15% maximum lifespan reduction at 25 C, 20% maximum lifespan reduction at 29 C.
% change in max lifespan
Maximum lifespan is up to 20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mutations resulted in reduced lifespan and increased sensitivity to oxidative stress while enhanced expression in older fly brains extended average adult lifespan by 56% and promoted resistance to oxidative stress.
    % change in avg or median lifespan
    Average lifespan is 56% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Increases the resistance to oxidative stress and extends the average lifespan up to 56%.
      % change in avg or median lifespan
      Average lifespan is up to 56% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Caenorhabditis elegans is present as lgg-1

        Homologs in other organisms

        Caenorhabditis elegans
        lgg-1
        Danio rerio
        gabarapa
        Homo sapiens
        GABARAPL3
        Mus musculus
        Gabarap
        Rattus norvegicus
        Gabarap

        External links

        FlyBase
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (32001)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar