Mus musculusGenAge entry for Atg5 (Mus musculus)

Gene information (ID: 1862)

Symbol
Atg5
Name
autophagy related 5
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Overexpression of Atg5 extends median lifespan of mice by 17.2%. Additionally, it enhances autophagy, and Atg5 transgenic mice show anti-ageing phenotypes, including leanness, increased insulin sensitivity and improved motor function.
% change in avg or median lifespan
Median lifespan is 17% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as atg-5
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG5
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG5

    Homologs in other organisms

    Caenorhabditis elegans
    atg-5
    Danio rerio
    atg5
    Drosophila melanogaster
    Atg5
    Homo sapiens
    ATG5
    Rattus norvegicus
    Atg5
    Saccharomyces cerevisiae
    ATG5
    Schizosaccharomyces pombe
    atg5

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (11793)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar