Mus musculusGenAge entry for Arhgap1 (Mus musculus)

Gene information (ID: 13)

Symbol
Arhgap1
Aliases
C76222; Cdc42GAP; p50rhoGAP; RP23-12H6.2; B230365D05Ri
Name
Rho GTPase activating protein 1
Organism
Mus musculus (AnAge)
Known functions and activities
Regulation of actin cytoskeleton organization, polarity, and growth

Potential relevance to longevity and/or ageing

Observations
Most knockout mice were weak and died during the neonatal period. Animals that survived had a shorter lifespan (median lifespan was 12 months) and showed premature ageing-like phenotypes, including a reduction in body mass, a loss of subdermal adipose tissue, lordokyphosis, and osteoporosis.
Lifespan Effect
Decrease
Genetic Manipulation
Knockout
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as ARHGAP1

    Homologs in other organisms

    Danio rerio
    arhgap1
    Homo sapiens
    ARHGAP1
    Rattus norvegicus
    Arhgap1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (228359)
    Homologues
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    UniProt
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    Internet
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