Drosophila melanogasterGenAge entry for AhcyL1 (Drosophila melanogaster)

Gene information (ID: 2084)

Symbol
AhcyL1
Name
Adenosylhomocysteinase like 1
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Downregulation of two out of three of Drosophila homologs of AHCY significantly extended life span in adult males and females, median lifespan was 13% higher when CG9977 was downregulated. Brain and intestine specific downregulation of CG9977 resulted in increased lifespan and health span.
% change in avg or median lifespan
Median lifespan is 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    zgc:158222
    Homo sapiens
    AHCYL1
    Mus musculus
    Ahcyl1

    External links

    FlyBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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