GenAge entry for Adra1b (Mus musculus)
Gene information (ID: 1954)
- adrenergic receptor, alpha 1b
- Mus musculus (AnAge)
Potential relevance to longevity and/or ageing
- Transgenic mice overexpressing a CAM form of the adrenergic receptor, alpha 1b (Adra1b), display a shorter lifespan (mean 11% shorter) when compared to wild-type mice. When comparing each sex separately, the mean lifespan difference was significant only for female mice. Maximal lifespan of mutant mice was significantly shorter than that of WT mice. Female mutants had a significantly shorter maximal lifespan than female WT animals, however, the maximal lifespan of male mutants was significantly increased when compared with that of male WT mice.
- % change in avg or median lifespan
- Mean lifespan is 11% lower.
- Lifespan Effect
- Genetic Manipulation
- Longevity Category
- Primary reference
Homologs in other organisms
No homologs found