Mus musculusGenAge entry for Adra1b (Mus musculus)

Gene information (ID: 1954)

Symbol
Adra1b
Name
adrenergic receptor, alpha 1b
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic mice overexpressing a CAM form of the adrenergic receptor, alpha 1b (Adra1b), display a shorter lifespan (mean 11% shorter) when compared to wild-type mice. When comparing each sex separately, the mean lifespan difference was significant only for female mice. Maximal lifespan of mutant mice was significantly shorter than that of WT mice. Female mutants had a significantly shorter maximal lifespan than female WT animals, however, the maximal lifespan of male mutants was significantly increased when compared with that of male WT mice.
% change in avg or median lifespan
Mean lifespan is 11% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Overexpression
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    No homologs found

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
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    Homologues
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    Internet
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