Mus musculusGenAge entry for Adra1a (Mus musculus)

Gene information (ID: 1953)

Symbol
Adra1a
Name
adrenergic receptor, alpha 1a
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Transgenic mice overexpressing a CAM form of the adrenergic receptor, alpha 1a (Adra1a), display an extended lifespan. Median lifespan taken for both sexes together is 10% higher than that of WT mice. While median lifespan increases for both sexes, this is significant for males only. Maximum lifespan also increases by 8% compared with WT mice.
% change in max lifespan
Maximum lifespan is 8% higher.
% change in avg or median lifespan
Median is 10% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    LOC798498
    Homo sapiens
    ADRA1A
    Rattus norvegicus
    Adra1a

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (11549)
    Homologues
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    UniProt
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    Internet
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