Drosophila melanogasterGenAge entry for 5-HT2A (Drosophila melanogaster)

Gene information (ID: 2089)

Symbol
5-HT2A
Name
5-hydroxytryptamine (serotonin) receptor 2A
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Flies were subjected to several control diets: sucrose only, yeast only and fixed diet. Flies were also subjected to a choice diet. When 5-HT2A mutant animals were aged in a choice environment there was a 90% increase in mean lifespan.
% change in avg or median lifespan
Mean lifespan is 90% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    htr2b
    Homo sapiens
    HTR2B
    Mus musculus
    Htr2b
    Rattus norvegicus
    Htr2b

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (40575)
    Homologues
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    UniProt
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    Internet
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