Drosophila melanogasterGenAge entry for 14-3-3epsilon (Drosophila melanogaster)

Gene information (ID: 831)

Symbol
14-3-3epsilon
Aliases
14-3-3; 14-3-3; epsilon; 14-3-3-e; 14-3-3-epsilon; 14-3
Name
CG31196 gene product from transcript CG31196-RA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Loss of 14-3-3e results in increased stress-induced apoptosis, growth repression and extended lifespan of flies, in a dFoxO dependent manner. Increased expression of 14-3-3e also reverts FoxO-induced growth defects. No effect on lifespan was observed when overexpressing 14-3-3e in adipose tissue, suggesting that endogenous FoxO activity in this tissue is low under normal conditions.
% change in avg or median lifespan
Average male lifespan is up to 25% higher; Average female lifespan is up to 49% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as BMH2

    Homologs in other organisms

    Danio rerio
    ywhae2
    Homo sapiens
    YWHAE
    Mus musculus
    Ywhae
    Rattus norvegicus
    Ywhae
    Saccharomyces cerevisiae
    BMH2
    Schizosaccharomyces pombe
    rad25

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42186)
    Homologues
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    UniProt
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    Internet
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