| GenAge Human Genes | Help | Human Ageing Genomic Resources | Citation |
| Gene name |
Common/alternative name |
Phenotype |
Primary reference |
Mouse (Mus musculus) |
|||
| Brca1 + p53 | breast cancer 1, early onset + tumour protector 53 | Signs of premature ageing in BRCA1 hypomorphic/p53 heterozygous mice. | Cao et al., 2003 |
| Bub3 + Rae1 | budding uninhibited by benzimidazoles 3 homolog, MRNP41 | BUB3/RAE1 haploinsufficient mice show signs of premature ageing. | Baker et al., 2006 |
| BubR1 | BUB1B | Signs of early onset of ageing in mice with low levels of BubR1. | Baker et al., 2004 |
| C/EBP | CCAAT/enhancer-binding protein | 20% increase in lifespan in C/EBP beta/beta mice. | Chiu et al., 2004 |
| GH | growth hormone | Putative accelerated ageing in transgenic mice. | Bartke, 2003 |
| GHR/BP | growth hormone receptor (Laron mouse) | Increase in lifespan of 40-50% in homozygous knock-outs. | Cochigano et al., 2000 |
| klotho | Potential accelerated ageing phenotype of homozygous knock-outs. | Kuro-o et al., 1997 | |
| Ku86 | XRCC5 | Signs of premature ageing due to homozygous mutation. | Vogel et al., 1999 |
| MsrA | methionine sulfoxide reductase A | Decreased lifespan and putative accelerated ageing in homozygous knock-outs. | Moskovitz et al., 2001 |
| p53 | tumour protector 53 | Heterozygous mutant mice show signs of accelerated ageing. | Tyner et al., 2002 |
| p63 | TP73L | Heterozygous mice display signs of premature ageing. | Keyes et al., 2005 |
| p66shc | SHC1 | Roughly 30% increase in lifespan in -/- mice. | Migliaccio et al., 1999 |
| PASG | proliferation associated SNF2-like gene | Phenotypes resembling accelerated ageing due to gene disruption. | Sun et al., 2004 |
| Pit1 | Snell dwarf mouse | Lifespan increase of 42% in homozygous mice. | Flurkey et al., 2001 |
| PolgA | mitochondrial DNA polymerase | Possible premature ageing in mice with a defective PolgA. | Trifunovic et al., 2004 |
| Prop1 | Ames dwarf mouse | Homozygous mice show over 50% increases in lifespan. | Brown-Borg et al., 1996 |
| SIRT6 | sirtuin 6 | SIRT6-deficient mice show signs of premature ageing. | Mostoslavsky et al., 2006 |
| Terc + Atm | telomerase RNA component + ataxia telangiectasia mutated | Signs of premature ageing in double mutant mice. | Wong et al., 2003 |
| Terc + WRN | telomerase RNA component + Werner syndrome | Signs of premature ageing in double mutant mice. | Chang et al., 2004 |
| uPA | urokinase-type plasminogen activator | Roughly 20% increase in lifespan of transgenic mice. | Miskin and Masos, 1997 |
| XPD | xeroderma pigmentosum, group D | Symptoms of premature ageing due to homozygous mutation. | de Boer et al., 2002 |
Human (Homo sapiens) |
|||
| CSA | Cockayne syndrome type I | Possible premature ageing due to recessive mutation. | Henning et al., 1995 |
| WRN | Werner syndrome | Possible accelerated ageing due to recessive mutation. | Yu et al., 1996 |
| LMNA | Hutchinson-Gilford syndrome | Possible premature ageing due to dominant mutation. | Eriksson et al., 2003 |
Please note: Gene names are in accordance with the primary reference. Also, only one reference per gene is displayed. Please consult the appropriate GenAge entry for additional bibliographical information.
Updated: 26/04/2006