GenAge Human Genes Help Human Ageing Genomic Resources Citation

Important notice: The option to search GenAge for genes associated with ageing in humans and mammalian animal models has rendered the list below of genes that appear to modulate mammalian ageing obsolete. Therefore, this list is considered deprecated, will not be updated again, and may be deleted sometime in the future. Users are encouraged to use GenAge's search functions to select genes associated with ageing on a given model system.

Genes that Appear to Modulate Mammalian Ageing

Gene name
Common/alternative name
Primary reference
Mouse (Mus musculus)
Brca1 + p53 breast cancer 1, early onset + tumour protector 53 Signs of premature ageing in BRCA1 hypomorphic/p53 heterozygous mice. Cao et al., 2003
Bub3 + Rae1 budding uninhibited by benzimidazoles 3 homolog, MRNP41 BUB3/RAE1 haploinsufficient mice show signs of premature ageing. Baker et al., 2006
BubR1 BUB1B Signs of early onset of ageing in mice with low levels of BubR1. Baker et al., 2004
C/EBP CCAAT/enhancer-binding protein 20% increase in lifespan in C/EBP beta/beta mice. Chiu et al., 2004
GH growth hormone Putative accelerated ageing in transgenic mice. Bartke, 2003
GHR/BP growth hormone receptor (Laron mouse) Increase in lifespan of 40-50% in homozygous knock-outs. Cochigano et al., 2000
klotho Potential accelerated ageing phenotype of homozygous knock-outs. Kuro-o et al., 1997
Ku86 XRCC5 Signs of premature ageing due to homozygous mutation. Vogel et al., 1999
MsrA methionine sulfoxide reductase A Decreased lifespan and putative accelerated ageing in homozygous knock-outs. Moskovitz et al., 2001
p53 tumour protector 53 Heterozygous mutant mice show signs of accelerated ageing. Tyner et al., 2002
p63 TP73L Heterozygous mice display signs of premature ageing. Keyes et al., 2005
p66shc SHC1 Roughly 30% increase in lifespan in -/- mice. Migliaccio et al., 1999
PASG proliferation associated SNF2-like gene Phenotypes resembling accelerated ageing due to gene disruption. Sun et al., 2004
Pit1 Snell dwarf mouse Lifespan increase of 42% in homozygous mice. Flurkey et al., 2001
PolgA mitochondrial DNA polymerase Possible premature ageing in mice with a defective PolgA. Trifunovic et al., 2004
Prop1 Ames dwarf mouse Homozygous mice show over 50% increases in lifespan. Brown-Borg et al., 1996
SIRT6 sirtuin 6 SIRT6-deficient mice show signs of premature ageing. Mostoslavsky et al., 2006
Terc + Atm telomerase RNA component + ataxia telangiectasia mutated Signs of premature ageing in double mutant mice. Wong et al., 2003
Terc + WRN telomerase RNA component + Werner syndrome Signs of premature ageing in double mutant mice. Chang et al., 2004
uPA urokinase-type plasminogen activator Roughly 20% increase in lifespan of transgenic mice. Miskin and Masos, 1997
XPD xeroderma pigmentosum, group D Symptoms of premature ageing due to homozygous mutation. de Boer et al., 2002

Human (Homo sapiens)
CSA Cockayne syndrome type I Possible premature ageing due to recessive mutation. Henning et al., 1995
WRN Werner syndrome Possible accelerated ageing due to recessive mutation. Yu et al., 1996
LMNA Hutchinson-Gilford syndrome Possible premature ageing due to dominant mutation. Eriksson et al., 2003

Please note: Gene names are in accordance with the primary reference. Also, only one reference per gene is displayed. Please consult the appropriate GenAge entry for additional bibliographical information.

GenAge database at the Human Ageing Genomic Resources

Updated: 26/04/2006