Life-extending drugs and compounds in Caenorhabditis elegans

Caenorhabditis elegans in DrugAge

Top life-extending compounds for Caenorhabditis elegans

Compound Name	Assays	Avg Lifespan Change (%)	Maximum Lifespan Change (%)
Ethanol	2	155.2
D-glutamate	3	114
N-butanol	1	108.1
N-propanol	1	95.5
Hydrogen Sulphide	1	74
Caffeine	24	65
Thioflavin T	1	60	78
Carbonylcyanide-3-chlorophenylhydrazone	1	60
Bacitracin	1	58.5	74
Paraquat	1	58	48
Metformin	11	57.3	0
Rifampicin	10	56.1
EUK-134	7	54
Taxifolin	1	51
Resveratrol	14	50.8	29.2
N-acetylglucosamine	1	50
Acetaminophen	1	48.6	59
Alpha-ketoglutarate	6	47.9
Shengmai yin	1	47.3
Trimethadione	7	47	57
Baicalein	2	45	52
Loxapine succinate	1	43
(R)-2-hydroxyglutarate	1	42.9
Psora-4	1	42
Electrolyzed reduced water	7	41	13.8
Ciclopirox olamine	1	41	52
Curcumin	2	39
Whole apple extract	1	39	25
Acacetin 7-O-alpha-l-rhamnopyranosyl (1_2) beta-D-xylopyranoside	5	39
Protocatechuic acid	2	38.9	40
Huanshao dan	1	38.3
Amperozide hydrochloride	1	38
EUK-8	19	38
Octoclothepin maleate	1	38
Crude BB extract (Vaccinium angustifolium)	1	37
Pergolide methanesulfonate	1	37
Proanthocycanidin	1	36.6
Doxycycline	5	36.5
Lithium Chloride	3	36	0
Ethosuximide	5	35	37
Reishi polysaccharide	1	35
Valproic acid	1	35	42
N-(2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl)-3-methoxybenzamide	1	35
LY-367,265	1	34
Sulfamethoxazole	3	34	0
Ampicillin	1	34
Dihydroergocristine methanesulfonate	1	34
Royalactin	3	33.9
Dimethyl formamide	1	33	54
Amoxapine	1	33

Summary	Total Assays: 659	Max: 155.2	Max: 78

	Compound Name	Avg Lifespan change (%)	Max Lifespan change (%)	Synonyms	Strain	Dosage	Gender	Significance

Compound Name	Avg Lifespan change (%)	Max Lifespan change (%)	Synonyms	Strain	Dosage	Gender	Significance	Reference

GenAge

Genes have been associated with ageing in this organism

GenDR