Vitamin E in DrugAge


SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Asplanchna brightwelli324.5 6.7
Caenorhabditis elegans1023 0
Mus musculus115
Drosophila melanogaster214
Paramecium tetraurelia111.7 17.1
Philodina19.2 0
Summary Total Assays: 18 Max: 24.5 Max: 17.1

Results for Vitamin E

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference


Primary References
Harrington, LA and Harley, CB (1988) Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech. Ageing Dev. 43(1)71-78 PubMed
Sawada, M and Enesco, HE (1984) Vitamin E extends lifespan in the short-lived rotifer Asplanchna brightwelli. Exp. Gerontol. 19(3)179-183 PubMed
Enesco, HE and Verdone-Smith, C (1980) alpha-Tocopherol increases lifespan in the rotifer Philodina. Exp. Gerontol. 15(5)335-338 PubMed
Miquel, J et al. (1982) Antioxidants, metabolic rate and aging in Drosophila. Arch Gerontol Geriatr 1(2)159-165 PubMed
Thomas, JN and Smith-Sonneborn, J (1997) Supplemental melatonin increases clonal lifespan in the protozoan Paramecium tetraurelia. J. Pineal Res. 23(3)123-130 PubMed
Adachi, H and Ishii, N (2000) Effects of tocotrienols on life span and protein carbonylation in Caenorhabditis elegans. J. Gerontol. A Biol. Sci. Med. Sci. 55(6)B280-B285 PubMed
Ishii, N et al. (2004) Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech. Ageing Dev. 125(1)41-46 PubMed
Sawada, M et al. (1990) The effects of UV radiation and antioxidants on life span and lipid peroxidation in the rotifer Asplanchna brightwelli. Arch Gerontol Geriatr 10(1)27-36 PubMed
Zou, S et al. (2007) Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech. Ageing Dev. 128(2)222-226 PubMed
Selman, C et al. (2008) Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage. Rejuvenation Res 11(1)83-96 PubMed

DGIdb human gene-drug interactions for Vitamin E

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Vitamin E

The data below is based on a Stitch DB API call for human protein-drug interactions for Vitamin E

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Vitamin E

Displayed below are the associated biological networks for each of the top 20 direct Vitamin E protein interactors.

Ensembl Id StringDB Id