DrugAge entry for Spermidine

Name
Spermidine 
Synonyms
(4-aminobutyl)(3-aminopropyl)amine • 1,4-Butanediamine, N-(3-aminopropyl)- • 1,4-Butanediamine, N1-(3-aminopropyl)- • 1,4-Diaminobutane, N-(3-aminopropyl)- • 1,5,10-Triazadecane • 1,8-Diamino-4-azaoctane • 124-20-9 • 4-Azaoctamethylenediamine • 4-Azaoctane-1,8-diamine • AI3-26636 • ATHGHQPFGPMSJY-UHFFFAOYSA-N • BRN 1698591 • CHEBI:16610 • CHEMBL19612 • EINECS 204-689-0 • MFCD00008229 • N'-(3-aminopropyl)butane-1,4-diamine • N-(3-Aminopropyl)-1,4-butane-diamine • N-(3-Aminopropyl)-1,4-butanediamine • N-(3-Aminopropyl)-1,4-diaminobutane • N-(3-aminopropyl)butane-1,4-diamine • N-[3-Aminopropyl]-1,4-butanediamine • N1-(3-Aminopropyl)butane-1,4-diamine • Spermidin • spermidine 
CAS Number
124-20-9 
IUPAC Name
N'-(3-aminopropyl)butane-1,4-diamine 
PubChem CID
1102 

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Spermidine


References

Eisenberg, T et al. (2009) Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11(11)1305-1314 PubMed
Yue F, et al. (2017) Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy Cancer Research () PubMed
Eisenberg T, et al. (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine Nature Medicine () PubMed

DGIdb Human Drug-Gene Interactions for Spermidine

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Spermidine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id