Resveratrol in DrugAge


SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Saccharomyces cerevisiae1170
Nothobranchius furzeri156 59
Caenorhabditis elegans1450.8 29.2
Nothobranchius guentheri542.9 32
Apis mellifera138
Drosophila melanogaster7620
Anastrepha ludens2415.6 36.3
Mus musculus24.7
Daphnia pulex clone TCO40
Summary Total Assays: 138 Max: 70 Max: 59

Results for Resveratrol

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference


Primary References
Howitz, KT et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954)191-196 PubMed
Wood, JG et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430(7000)686-689 PubMed
Kaeberlein, M et al. (2005) Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280(17)17038-17045 PubMed
Viswanathan, M et al. (2005) A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev. Cell 9(5)605-615 PubMed
Valenzano, DR et al. (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol. 16(3)296-300 PubMed
Yang, H et al. (2007) Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell 6(1)35-43 PubMed
Gruber, J et al. (2007) Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans. Ann. N. Y. Acad. Sci. 1100()530-542 PubMed
Bass, TM et al. (2007) Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128(10)546-552 PubMed
Zou, S et al. (2009) The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly. Exp. Gerontol. 44(6-7)472-476 PubMed
Morselli, E et al. (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1()e10 PubMed
Wang, C et al. (2013) The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster. Age (Dordr) 35(1)69-81 PubMed
Strong, R et al. (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 68(1)6-16 PubMed
Sun, K et al. (2012) Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. Biosci. Biotechnol. Biochem. 76(4)640-645 PubMed
Rascón, B et al. (2012) The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY) 4(7)499-508 PubMed
Yu, X and Li, G (2012) Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri. Exp. Gerontol. 47(12)940-949 PubMed
Genade, T and Lang, DM (2013) Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum. Exp. Gerontol. 48(2)202-212 PubMed
Sun, K et al. (2013) A Steroidal Saponin from Ophiopogon japonicus Extends the Lifespan of Yeast via the Pathway Involved in SOD and UTH1. Int J Mol Sci 14(3)4461-4475 PubMed
Houtkooper, RH et al. (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497(7450)451-457 PubMed
Kim, E et al. (2014) Resveratrol and food effects on lifespan and reproduction in the model crustacean Daphnia. J Exp Zool A Ecol Genet Physiol 321(1)48-56 PubMed
Liu, T et al. (2015) Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri. Rejuvenation Res 18(3)225-233 PubMed
Kim, J et al. (2015) The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1. Mol. Cell. Endocrinol. 412()216-225 PubMed

DGIdb human gene-drug interactions for Resveratrol

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Resveratrol

The data below is based on a Stitch DB API call for human protein-drug interactions for Resveratrol

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.


Displayed below are the associated biological networks for each of the top 20 direct Resveratrol protein interactors.

Ensembl Id StringDB Id