Rapamycin in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Caenorhabditis elegans420.6
Mus musculus916 14
Drosophila melanogaster113
Summary Total Assays: 14 Max: 20.6 Max: 14

Results for Rapamycin

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Harrison, DE et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460(7253)392-395 PubMed
Chen, C et al. (2009) mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal 2(98)ra75 PubMed
Bjedov, I et al. (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11(1)35-46 PubMed
Anisimov, VN et al. (2011) Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle 10(24)4230-4236 PubMed
Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5)713-724 PubMed
Zhang, Y et al. (2014) Rapamycin extends life and health in C57BL/6 mice. J. Gerontol. A Biol. Sci. Med. Sci. 69(2)119-130 PubMed
Houtkooper, RH et al. (2013) Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 497(7450)451-457 PubMed
Neff, F et al. (2013) Rapamycin extends murine lifespan but has limited effects on aging. J. Clin. Invest. 123(8)3272-3291 PubMed
Miller, RA et al. (2014) Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 13(3)468-477 PubMed
Fok, WC et al. (2014) Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS ONE 9(1)e83988 PubMed
Calvert, S et al. (2016) A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans. Aging Cell 15(2)256-266 PubMed

DGIdb human gene-drug interactions for Rapamycin

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Rapamycin

The data below is based on a Stitch DB API call for human protein-drug interactions for Rapamycin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Rapamycin

Displayed below are the associated biological networks for each of the top 20 direct Rapamycin protein interactors.

Ensembl Id StringDB Id