Nordihydroguaiaretic acid in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Aedes aegypti564.3
Drosophila melanogaster223
Mus musculus512 0
Summary Total Assays: 12 Max: 64.3 Max: 0

Results for Nordihydroguaiaretic acid

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Richie, JP et al. (1986) Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc. Soc. Exp. Biol. Med. 183(1)81-85 PubMed
Strong, R et al. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7(5)641-650 PubMed
Spindler, SR et al. (2015) Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice. J. Gerontol. A Biol. Sci. Med. Sci. 70(12)1479-1489 PubMed

DGIdb human gene-drug interactions for Nordihydroguaiaretic acid

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Nordihydroguaiaretic acid

The data below is based on a Stitch DB API call for human protein-drug interactions for Nordihydroguaiaretic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Nordihydroguaiaretic acid

Displayed below are the associated biological networks for each of the top 20 direct Nordihydroguaiaretic acid protein interactors.

Ensembl Id StringDB Id