N-acetyl-L-cysteine in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Caenorhabditis elegans730.5 47.1
Drosophila melanogaster326.8 24.5
Mus musculus124 45
Summary Total Assays: 11 Max: 30.5 Max: 47.1

Results for N-acetyl-L-cysteine

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Brack, C et al. (1997) N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cell. Mol. Life Sci. 53(11-12)960-966 PubMed
Shibamura, A et al. (2009) A method for oral administration of hydrophilic substances to Caenorhabditis elegans: Effects of oral supplementation with antioxidants on the nematode lifespan. Mech. Ageing Dev. 130(9)652-655 PubMed
Flurkey, K et al. (2010) Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 65(12)1275-1284 PubMed
Oh, SI et al. (2015) Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo) 70(5)380-386 PubMed

DGIdb human gene-drug interactions for N-acetyl-L-cysteine

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for N-acetyl-L-cysteine

The data below is based on a Stitch DB API call for human protein-drug interactions for N-acetyl-L-cysteine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

N-acetyl-L-cysteine

Displayed below are the associated biological networks for each of the top 20 direct N-acetyl-L-cysteine protein interactors.

Ensembl Id StringDB Id