Metformin in DrugAge


SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Acheta domesticus279
Caenorhabditis elegans1157.3 0
Drosophila melanogaster157
Mus musculus15.8
Rattus norvegicus12.3 2.1
Summary Total Assays: 30 Max: 79 Max: 2.1

Results for Metformin

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference


Primary References
Smith, DL et al. (2010) Metformin supplementation and life span in Fischer-344 rats. J. Gerontol. A Biol. Sci. Med. Sci. 65(5)468-474 PubMed
Onken, B and Driscoll, M (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS ONE 5(1)e8758 PubMed
Slack, C et al. (2012) Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. PLoS ONE 7(10)e47699 PubMed
Martin-Montalvo, A et al. (2013) Metformin improves healthspan and lifespan in mice. Nat Commun 4()2192 PubMed
De Haes, W et al. (2014) Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc. Natl. Acad. Sci. U.S.A. 111(24)E2501-E2509 PubMed
Hans, H et al. (2015) Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension? Age (Dordr) 37(2)31 PubMed

DGIdb human gene-drug interactions for Metformin

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Metformin

The data below is based on a Stitch DB API call for human protein-drug interactions for Metformin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.


Displayed below are the associated biological networks for each of the top 20 direct Metformin protein interactors.

Ensembl Id StringDB Id