Melatonin in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Paramecium tetraurelia422.8 20.9
Mus musculus218.1 7.5
Drosophila melanogaster314 33
Summary Total Assays: 9 Max: 22.8 Max: 33

Results for Melatonin

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Pierpaoli, W and Regelson, W (1994) Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. U.S.A. 91(2)787-791 PubMed
Thomas, JN and Smith-Sonneborn, J (1997) Supplemental melatonin increases clonal lifespan in the protozoan Paramecium tetraurelia. J. Pineal Res. 23(3)123-130 PubMed
Izmaylov, DM and Obukhova, LK (1999) Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster. Mech. Ageing Dev. 106(3)233-240 PubMed
Anisimov, VN et al. (2001) Melatonin increases both life span and tumor incidence in female CBA mice. J. Gerontol. A Biol. Sci. Med. Sci. 56(7)B311-B323 PubMed
Bonilla, E et al. (2002) Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin. Exp. Gerontol. 37(5)629-638 PubMed

DGIdb human gene-drug interactions for Melatonin

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Melatonin

The data below is based on a Stitch DB API call for human protein-drug interactions for Melatonin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Melatonin

Displayed below are the associated biological networks for each of the top 20 direct Melatonin protein interactors.

Ensembl Id StringDB Id