L-deprenyl in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Rattus norvegicus516.7 17
Mus musculus47 31.2
Mesocricetus auratus1 16.4
Canis lupus familiaris1
Summary Total Assays: 11 Max: 16.7 Max: 31.2

Results for L-deprenyl

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Milgram, NW et al. (1990) Maintenance on L-deprenyl prolongs life in aged male rats. Life Sci. 47(5)415-420 PubMed
Kitani, K et al. (1994) (-)Deprenyl increases the life span as well as activities of superoxide dismutase and catalase but not of glutathione peroxidase in selective brain regions in Fischer rats. Ann. N. Y. Acad. Sci. 717()60-71 PubMed
Kitani, K et al. (1993) Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats. Further evidence. Life Sci. 52(3)281-288 PubMed
Archer, JR and Harrison, DE (1996) L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males. J. Gerontol. A Biol. Sci. Med. Sci. 51(6)B448-B453 PubMed
Stoll, S et al. (1997) Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males. Neurobiol. Aging 18(2)205-211 PubMed
Ruehl, WW et al. (1997) Treatment with L-deprenyl prolongs life in elderly dogs. Life Sci. 61(11)1037-1044 PubMed
Kitani, K et al. (2005) Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl. Biogerontology 6(5)297-302 PubMed

DGIdb human gene-drug interactions for L-deprenyl

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for L-deprenyl

The data below is based on a Stitch DB API call for human protein-drug interactions for L-deprenyl

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

L-deprenyl

Displayed below are the associated biological networks for each of the top 20 direct L-deprenyl protein interactors.

Ensembl Id StringDB Id