Curcumin in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Drosophila melanogaster3149 49
Caenorhabditis elegans239
Mus musculus24.5
Summary Total Assays: 35 Max: 49 Max: 49

Results for Curcumin

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Lee, KS et al. (2010) Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res 13(5)561-570 PubMed
Liao, VH et al. (2011) Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mech. Ageing Dev. 132(10)480-487 PubMed
Strong, R et al. (2013) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J. Gerontol. A Biol. Sci. Med. Sci. 68(1)6-16 PubMed
Shen, LR et al. (2013) Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Age (Dordr) 35(4)1133-1142 PubMed
Soh, JW et al. (2013) Curcumin is an early-acting stage-specific inducer of extended functional longevity in Drosophila. Exp. Gerontol. 48(2)229-239 PubMed
Suckow, BK and Suckow, MA (2006) Lifespan extension by the antioxidant curcumin in Drosophila melanogaster. Int J Biomed Sci 2(4)402-405 PubMed
Chandrashekara, KT et al. (2014) Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster. Age (Dordr) 36(5)9702 PubMed
Li, J et al. (2015) rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Exp. Gerontol. 67()62-71 PubMed
Arking, R. (2015) Independent chemical regulation of health and senescent spans in Drosophila. Invertebr. Reprod. Dev. 59(sup1)28-32 PubMed

DGIdb human gene-drug interactions for Curcumin

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Curcumin

The data below is based on a Stitch DB API call for human protein-drug interactions for Curcumin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Curcumin

Displayed below are the associated biological networks for each of the top 20 direct Curcumin protein interactors.

Ensembl Id StringDB Id