Caffeine in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Saccharomyces cerevisiae186
Caenorhabditis elegans2465
Drosophila melanogaster31.7
Summary Total Assays: 28 Max: 86 Max:

Results for Caffeine

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Massie, HR et al. (1993) Inhibition of iron absorption prolongs the life span of Drosophila. Mech. Ageing Dev. 67(3)227-237 PubMed
Wanke, V et al. (2008) Caffeine extends yeast lifespan by targeting TORC1. Mol. Microbiol. 69(1)277-285 PubMed
Sutphin, GL et al. (2012) Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longev Healthspan 1()9 PubMed
Bridi, JC et al. (2015) Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling. Front Aging Neurosci 7()220 PubMed

DGIdb human gene-drug interactions for Caffeine

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Caffeine

The data below is based on a Stitch DB API call for human protein-drug interactions for Caffeine

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Caffeine

Displayed below are the associated biological networks for each of the top 20 direct Caffeine protein interactors.

Ensembl Id StringDB Id