Alpha-ketoglutarate in DrugAge

Summary

SpeciesAssaysAvg Lifespan Change (%)Maximum Lifespan Change (%)
Caenorhabditis elegans647.9
Summary Total Assays: 6 Max: 47.9 Max:

Results for Alpha-ketoglutarate

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance

Selected Lifespan Change:

Species Avg Lifespan change (%) Max Lifespan change (%) Strain Dosage Gender Significance Reference

References

Primary References
Chin, RM et al. (2014) The metabolite \u03b1-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510(7505)397-401 PubMed
Edwards, C et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet. 16()8 PubMed
Fu, X et al. (2015) 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 22(3)508-515 PubMed

DGIdb human gene-drug interactions for Alpha-ketoglutarate

Entrez Gene Symbol Gene Name Interaction Source Interaction Type GenAge Interactions

Stitch DB human protein-drug interactions for Alpha-ketoglutarate

The data below is based on a Stitch DB API call for human protein-drug interactions for Alpha-ketoglutarate

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above.

Alpha-ketoglutarate

Displayed below are the associated biological networks for each of the top 20 direct Alpha-ketoglutarate protein interactors.

Ensembl Id StringDB Id