Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: hsf-1

Gene Information (Entrez Gene ID: 173078)

Symbol
hsf-1
Name
Heat Shock Factor 1
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
173078

Potential relevance to dietary restriction and ageing

Observations

RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signalling [985]. hsf-1 overexpression extends mean, median, and maximum lifespan by 37, 35, and 29% [2588]. hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [626]. A mutant allele of hsf-1 slightly decreases lifespan under ad lib, but cancels out the lifespan extension effect of bacterial dilution DR [2565]. Solid DR extends the lifespan of hsf-1 mutant with a premature stop codon, that eliminates activation domain, and that of wild-type to a similar extent [2568]. In another experiment, hsf-1 RNAi attenuated lifespan extension by bacterial dilution DR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuated protection against oxidative stress by bacterial dilution DR. hsf-1 expression was induced by bacterial dilution DR [2569].

References

    In other databases

    GenAge model organism genes
    • This gene is present as hsf-1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as HSF1

    Homologs

    Homo sapiens
    HSF1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 173078
    Homologues
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    UniProt
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    Internet
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