Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: atg-7

Gene Information (Entrez Gene ID: 178005)

Symbol
atg-7
Name
AuTophaGy (yeast Atg homolog) 7
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
178005

Potential relevance to dietary restriction and ageing

Observations

RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg-7 RNAi does not affect lifespan of wild-type, but cancels out the lifespan extension effect of eat-2 mutation, a genetic model of DR [2244].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Atg7
    • This gene is present as atg-7
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7

    Homologs

    Danio rerio
    uncharacterized_E7F5
    Drosophila melanogaster
    Atg7
    Homo sapiens
    ATG7
    Mus musculus
    Atg7
    Rattus norvegicus
    Atg7
    Saccharomyces cerevisiae
    ATG7
    Schizosaccharomyces pombe
    atg7

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 178005
    Homologues
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    UniProt
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    Internet
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