Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: rab-10

Gene Information (Entrez Gene ID: 266836)

Symbol
rab-10
Name
RAB family
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
266836

Potential relevance to dietary restriction and ageing

Observations

rab-10 RNA interference significantly extends lifespan of wild-type by 14 - 16%, of daf-16 mutants by 47%, and of daf-2 by 46%, but fails to significantly further extend lifespan of eat-2 mutants, a genetic model of DR. rab-10 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as cause a slender appearance. rab-10 mRNA is 2-fold downregulated in response to DR [2240].

References

    In other databases

    GenAge model organism genes
    • This gene is present as rab-10

    Homologs

    Danio rerio
    rab10
    Drosophila melanogaster
    Rab10
    Drosophila melanogaster
    RabX4
    Homo sapiens
    RAB10
    Mus musculus
    Rab10
    Rattus norvegicus
    Rab10
    Saccharomyces cerevisiae
    SEC4

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 266836
    Homologues
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    UniProt
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    Internet
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