Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Men

Gene Information (Entrez Gene ID: 47173)

Symbol
Men
Aliases
anon-WO0118547.278 CG10120 Dmel\CG10120 MDH Mdh-NADP Me ME mem men MEN
Name
Malic enzyme
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
47173

Potential relevance to dietary restriction and ageing

Observations

A mutation that decreased Men activity (52% of the wild type) in flies lowered lifespan. Flies with mutant Men didn't display an increase in lifespan when subjected to dietary restriction, whereas wild type flies demonstrated a significant increase in lifespan, thus indicating that Men activity is required for the lifespan extending effects of dietary restriction.

References

    In other databases

    GenAge model organism genes
    • This gene is present as Men

    Homologs

    Caenorhabditis elegans
    men-1
    Danio rerio
    uncharacterized_H9GX
    Homo sapiens
    ME1
    Mus musculus
    Me1
    Rattus norvegicus
    Me3

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 47173
    Homologues
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    UniProt
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    Internet
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