Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Men

Gene Information (Entrez Gene ID: 47173)

Symbol
Men
Aliases
anon-WO0118547.278 CG10120 Dmel\CG10120 MDH Mdh-NADP Me ME mem men MEN
Name
Malic enzyme
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
47173

Potential relevance to dietary restriction and ageing

Observations

A mutation that decreased Men activity (52% of the wild type) in flies lowered lifespan. Flies with mutant Men didn't display an increase in lifespan when subjected to dietary restriction, whereas wild type flies demonstrated a significant increase in lifespan, thus indicating that Men activity is required for the lifespan extending effects of dietary restriction.

References

    In other databases

    GenAge model organism genes
    • This gene is present as Men
    CellAge
    • A homolog of this gene for Homo sapiens is present as ME1
    • A homolog of this gene for Homo sapiens is present as ME2

    Homologs

    Caenorhabditis elegans
    men-1
    Danio rerio
    me2
    Danio rerio
    CABZ01025780.1
    Danio rerio
    me1
    Danio rerio
    me3
    Homo sapiens
    ME2
    Homo sapiens
    ME1
    Homo sapiens
    ME3
    Mus musculus
    Me1
    Mus musculus
    Me3
    Mus musculus
    Me2
    Rattus norvegicus
    Me2
    Rattus norvegicus
    Me1
    Rattus norvegicus
    Me3
    Saccharomyces cerevisiae
    MAE1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 47173
    Homologues
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    UniProt
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    Internet
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