GenDR Dietary Restriction Gene Manipulation: cha-1
Gene Information (Entrez Gene ID: 13192683)
- abnormal CHoline Acetyltransferase 1
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
Mutation or RNA interference of cha-1 extends lifespan on killed or live bacteria as well as in liquid culture medium . cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants . cha-1 participates in determining pharyngeal pumping rate to affect food intake .
- Drosophila melanogaster