Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Cbs

Gene Information (Entrez Gene ID: 33081)

Symbol
Cbs
Aliases
CBS CG1753 dCBS Dmel\CG1753
Name
Cystathionine beta-synthase
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
33081

Potential relevance to dietary restriction and ageing

Observations

Ubiquitous or neuron-specific overexpression of Cbs enhances longevity in fully-fed animals. Cbs RNAi partly abrogates increased lifespan by DR, but has no effect on fully fed animals. It appears that Cbs upregulation is required for increased lifespan under low-nutrient conditions. Response of male flies to DR is muted in comparison with females [2589].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as CYS4
    • This gene is present as Cbs

    Homologs

    Caenorhabditis elegans
    cysl-4
    Danio rerio
    cbsa
    Homo sapiens
    CBS
    Mus musculus
    Cbs
    Rattus norvegicus
    Cbs
    Saccharomyces cerevisiae
    CYS4
    Schizosaccharomyces pombe
    cys12

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 33081
    Homologues
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    UniProt
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    Internet
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