Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: HST2

Gene Information (Entrez Gene ID: 856092)

Symbol
HST2
Name
Homolog of SIR Two (SIR2) 2
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
856092

Potential relevance to dietary restriction and ageing

Observations

HST2 overexpression extends replicative lifespan. 0.5% glucose restriction does not increase lifespan of sir2;fob1;hst2 triple mutants [2309]. DR increases lifespan of all four sir2;fob1;hstX(X = sirtuin) triple mutants [2558].

References

    In other databases

    GenAge model organism genes
    • This gene is present as HST2
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Drosophila melanogaster is present as Sirt2
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1

    Homologs

    Caenorhabditis elegans
    sir-2.1
    Danio rerio
    sirt3
    Drosophila melanogaster
    Sirt2
    Homo sapiens
    SIRT2
    Mus musculus
    Sirt3
    Rattus norvegicus
    Sirt2
    Schizosaccharomyces pombe
    hst2

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 856092
    Homologues
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    UniProt
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    Internet
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