Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: foxo

Gene Information (Entrez Gene ID: 41709)

Symbol
foxo
Aliases
3143 Afx anon-WO0118547.374 cg3143 CG3143 dfoxo dFoxo dFoxO dFOXO Dfoxo Dmel\CG3143 DmQ95V5 fd88A FKHR foxO Foxo FoxO FOXO foxo|dFOXO Q95V55
Name
Forkhead box, sub-group O
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
41709

Potential relevance to dietary restriction and ageing

Observations

foxo overexpression extends lifespan. Activation of foxo in the adult pericerebral fat body is sufficient for lifespan extension. Limited activation of foxo reduces the expression of Drosophila insulin-like peptide dilp-2 synthesised in neurons and, represses endogenous insulin-dependent signalling in peripheral fat body [1091]. foxo is not required for DR, but its activity modulates the response. foxo null mutants are shorter-lived than wild-type on all food dilutions apart from 0.1 SY and under starvation. foxo overexpression in adult fat body under normal nutrition leads to extension of lifespan of females and causes an attenuated lifespan response to DR [2578].

References

    In other databases

    GenAge model organism genes
    • This gene is present as foxo
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as FOXO4
    GenDR gene manipulations
    • A homolog of this gene for Mus musculus is present as Foxo3
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as FOXO4

    Homologs

    Caenorhabditis elegans
    let-381
    Danio rerio
    si:ch211-206a7.2
    Homo sapiens
    FOXO4
    Mus musculus
    Foxo3
    Rattus norvegicus
    Foxo3

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    ID 41709
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar