Caenorhabditis elegans GenDR Dietary Restriction Gene Manipulation: aak-2

Gene Information (Entrez Gene ID: 181727)

Symbol
aak-2
Name
AMP-Activated Kinase 2
Organism
Caenorhabditis elegans (AnAge)
Entrez Gene ID
181727

Potential relevance to dietary restriction and ageing

Observations

AAK-2 could be a sensor that couples energy levels and insulin-like signals to lifespan. aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [2232]. Solid DR increases AMP:ATP ratio. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from solid DR. A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [2564]. aak-2 mutation cancels out the lifespan extension effect of solid DR and peptone dilution, regardless of the concentration of bacteria or peptones. Bacterial dilution DR significantly extends lifespan of aak-2 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type.

References

    In other databases

    GenAge model organism genes
    • This gene is present as aak-2
    • A homolog of this gene for Drosophila melanogaster is present as SNF1A

    Homologs

    Drosophila melanogaster
    SNF1A
    Danio rerio
    prkaa2
    Homo sapiens
    NIM1
    Mus musculus
    Prkaa1
    Rattus norvegicus
    Prkaa1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    ID 181727
    Homologues
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    UniProt
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    Internet
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