GenDR Dietary Restriction Gene Manipulation: FKH2
Gene Information (Entrez Gene ID: 855656)
- ForK head Homolog 2
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
Potential relevance to dietary restriction and ageing
Deletion of FKH1 or FKH2 has no effect on neither replicative nor chronological lifespan . Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in slight increased chronological and replicative lifespan as well as stress resistance .
- Danio rerio