Cell Senescence-associated Genes

Found 28 results. Showing results 1 to 20.

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Gene Name Method Cell Types Cell Lines Cancer Cell Line? Senescence Type Senescence Effect
AKT1OverexpressionAortic endothelial, Umbilical vein endothelial, Dermal microvascular endothelial cellsPrimary cellNoOncogene-inducedPromotes
ASF1AKnockout, OverexpressionLung fibroblastPrimary cellNoReplicative, Oncogene-inducedPromotes
BRAFOverexpressionForeskin fibroblast, MelanocytePrimary cell, BJNoOncogene-inducedPromotes
CXCL1OverexpressionOvarian fibroblastGro-1NoOncogene-inducedPromotes
DDB2KnockoutLung fibroblastIMR-90NoOncogene-inducedPromotes
DHCR24MutationLung fibroblastWI-38NoOncogene-inducedPromotes
ETS1OverexpressionLung fibroblast, Foreskin fibroblastTIG-3, Hs68NoOncogene-inducedPromotes
ETS2OverexpressionForeskin fibroblast, Lung fibroblastTIG-3, Hs68NoOncogene-inducedPromotes
HRASOverexpressionLung fibroblastIMR-90, WI-38NoOncogene-inducedPromotes
MAGEA2OverexpressionForeskin fibroblastBJNoOncogene-inducedInhibits
MAP2K2OverexpressionLung fibroblastIMR-90NoOncogene-inducedPromotes
MAPKAPK5KnockoutForeskin fibroblastBJNoOncogene-inducedPromotes
MYCKnockoutFibroblastLF1NoOncogene-inducedInhibits
NR2E1KnockoutProstate epithelial, Lung fibroblast, Neural StemIMR-90, WI-38NoOncogene-inducedUnclear
PDCD10KnockoutCoronary artery endothelial, Lung fibroblastPrimary cell, IMR-90NoReplicative, Oncogene-inducedPromotes
PIM1Overexpression, KnockdownForeskin fibroblast, Lung fibroblast2BS, BJ, WI-38NoOncogene-induced, ReplicativePromotes
PMLOverexpressionLung fibroblastWI-38NoOncogene-inducedPromotes
RAF1OverexpressionLung fibroblastIMR-90NoOncogene-inducedPromotes
SFNOverexpressionMelanomaSK-MEL-19, SK-MEL-29, SK-MEL-147YesOncogene-inducedPromotes
SOCS1Knockdown, OverexpressionLung fibroblastIMR-90NoReplicative, Oncogene-inducedPromotes