Cell Senescence-associated Genes

Found 28 results. Showing results 1 to 20.

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Gene Name Method Cell Types Cell Lines Cancer Cell Line? Senescence Type Senescence Effect
AKT1OverexpressionAortic endothelial, Dermal microvascular endothelial cells, Umbilical vein endothelialPrimary cellNoOncogene-inducedPromotes
ASF1AKnockout, OverexpressionLung fibroblastPrimary cellNoOncogene-induced, ReplicativePromotes
BRAFOverexpressionForeskin fibroblast, MelanocyteBJ, Primary cellNoOncogene-inducedPromotes
CXCL1OverexpressionOvarian fibroblastGro-1NoOncogene-inducedPromotes
DDB2KnockoutLung fibroblastIMR-90NoOncogene-inducedPromotes
DHCR24MutationLung fibroblastWI-38NoOncogene-inducedPromotes
ETS1OverexpressionForeskin fibroblast, Lung fibroblastHs68, TIG-3NoOncogene-inducedPromotes
ETS2OverexpressionForeskin fibroblast, Lung fibroblastHs68, TIG-3NoOncogene-inducedPromotes
HRASOverexpressionLung fibroblastIMR-90, WI-38NoOncogene-inducedPromotes
MAGEA2OverexpressionForeskin fibroblastBJNoOncogene-inducedInhibits
MAP2K2OverexpressionLung fibroblastIMR-90NoOncogene-inducedPromotes
MAPKAPK5KnockoutForeskin fibroblastBJNoOncogene-inducedPromotes
MYCKnockoutFibroblastLF1NoOncogene-inducedInhibits
NR2E1KnockoutLung fibroblast, Neural Stem, Prostate epithelialIMR-90, WI-38NoOncogene-inducedUnclear
PDCD10KnockoutCoronary artery endothelial, Lung fibroblastIMR-90, Primary cellNoOncogene-induced, ReplicativePromotes
PIM1Knockdown, OverexpressionForeskin fibroblast, Lung fibroblast2BS, BJ, WI-38NoOncogene-induced, ReplicativePromotes
PMLOverexpressionLung fibroblastWI-38NoOncogene-inducedPromotes
RAF1OverexpressionLung fibroblastIMR-90NoOncogene-inducedPromotes
SFNOverexpressionMelanomaSK-MEL-147, SK-MEL-19, SK-MEL-29YesOncogene-inducedPromotes
SOCS1Knockdown, OverexpressionLung fibroblastIMR-90NoOncogene-induced, ReplicativePromotes